文献类型： 外文期刊
第一作者： Han Hao
作者： Han Hao;Zhang Bo;Zhang Mei;Shi Jing;Li Wei;Jiao Rui-Hua;Tan Ren-Xiang;Ge Hui-Ming;Guo Zhi-Kai;Tan Ren-Xiang
作者机构：
关键词： Earwig-associated actinomycete; Phenazine; Biosynthetic pathway; Antimicrobial activity; Acetylcholinesterase inhibitory activity
期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：3.0； 五年影响因子：2.869 ）
ISSN： 2095-6975
年卷期： 2019 年 17 卷 6 期
页码：
收录情况： SCI
摘要： Three new phenazine-type compounds, named phenazines SA-SC (1-3), together with four new natural products (4-7), were isolated from the fermentation broth of an earwig-associated Streptomyces sp. NA04227. The structures of these compounds were determined by extensive analyses of NMR, high resolution mass spectroscopic data, as well as single-crystal X-ray diffraction measurement. Sequencing and analysis of the genome data allowed us to identify the gene cluster (spz) and propose a bio-synthetic pathway for these phenazine-type compounds. Additionally, compounds 1-5 exhibited moderate inhibitory activity against acetylcholinesterase (AChE), and compound 3 showed antimicrobial activities against Micrococcus luteus.
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