Antibacterial, antidiarrheal, anti-inflammatory and analgesic activities of compound Shikuqin powder

文献类型： 外文期刊

第一作者： Yu, Bo

作者： Yu, Bo;Yu, Jiankang;Jiang, Lingling;Zhou, Sixuan;Xu, Jinge;Shang, Yishun;Chen, Xiangxiu;Song, Xu;Wu, Jie;Tu, Zhiqiang;Song, Zhiling;Yin, Zhongqiong;Yu, Jiankang

作者机构：

关键词： Analgesic; antibacterial; antidiarrheal; anti-inflammatory; compound Shikuqin powder

期刊名称：PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES （ 影响因子：0.684； 五年影响因子：0.804 ）

ISSN： 1011-601X

年卷期： 2019 年 32 卷 3 期

页码：

收录情况： SCI

摘要： The MIC and MBC values of Shikuqin (SKQ) against 5 bacteria that readily cause diarrhea were measured by the broth micro dilution method. The castor oil-induced diarrhea method was used to evaluate the antidiarrheal activity. Intestinal transit and gastric emptying were also evaluated with normal and neostigmine-induced intestinal transit in rodents. In addition, the antidiarrheal activity of SKQ was assessed in vivo with isolated rabbit ileum. Xylene-induced ear edema was used to evaluate the anti-inflammatory activities in mice, while hot plate and writhing tests were performed to assess the analgesic effects. Senna decoction (0.3g/mL) was administered intragastrically to induce a rat model of diarrhea. Semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect AQP4 mRNA, and Western blot was performed to quantify the protein level of AQP4 in the colon. SKQ exhibits remarkable antidiarrheal, anti-inflammatory and analgesic effects in the gastrointestinal tract disorders, and can therefore be developed as a promising antidiarrheal agent.

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