Analysis of Hematological Traits in Polled Yak by Genome-Wide Association Studies Using Individual SNPs and Haplotypes

文献类型： 外文期刊

第一作者： Ma, Xiaoming

作者： Ma, Xiaoming;Jia, Congjun;Fu, Donghai;Chu, Min;Ding, Xuezhi;Wu, Xiaoyun;Guo, Xian;Pei, Jie;Bao, Pengjia;Liang, Chunnian;Yan, Ping;Ma, Xiaoming;Jia, Congjun;Fu, Donghai;Chu, Min;Ding, Xuezhi;Wu, Xiaoyun;Guo, Xian;Pei, Jie;Bao, Pengjia;Liang, Chunnian;Yan, Ping

作者机构：

关键词： single-marker GWAS; haplotype analysis; hematological traits; polled yak

期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）

ISSN： 2073-4425

年卷期： 2019 年 10 卷 6 期

页码：

收录情况： SCI

摘要： Yak (Bos grunniens) is an important domestic animal living in high-altitude plateaus. Due to inadequate disease prevention, each year, the yak industry suffers significant economic losses. The identification of causal genes that affect blood- and immunity-related cells could provide preliminary reference guidelines for the prevention of diseases in the population of yaks. The genome-wide association studies (GWASs) utilizing a single-marker or haplotype method were employed to analyze 15 hematological traits in the genome of 315 unrelated yaks. Single-marker GWASs identified a total of 43 significant SNPs, including 35 suggestive and eight genome-wide significant SNPs, associated with nine traits. Haplotype analysis detected nine significant haplotype blocks, including two genome-wide and seven suggestive blocks, associated with seven traits. The study provides data on the genetic variability of hematological traits in the yak. Five essential genes (GPLD1, EDNRA, APOB, HIST1H1E, and HIST1H2BI) were identified, which affect the HCT, HGB, RBC, PDW, PLT, and RDWSD traits and can serve as candidate genes for regulating hematological traits. The results provide a valuable reference to be used in the analysis of blood properties and immune diseases in the yak.

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