Three forms of cocaine- and amphetamine-regulated transcript may be involved in food intake regulation in gibel carp (Carassius auratus gibelio)

文献类型： 外文期刊

第一作者： Zhou, Chaowei

作者： Zhou, Chaowei;Lei, Luo;Deng, Xingxing;Zhu, Chengke;Ye, Hua;Luo, Hui;Yang, Minmin;Wang, Jian;Zheng, Zonglin;Zhou, Chaowei;Zhang, Chi;Zhou, Jianshe;Zeng, Benhe;Li, Baohai;Yuan, Dengyue

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关键词： Cocaine- and amphetamine-regulated transcript; Cloning; Fasting; Feeding; Gibel carp

期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：2.794； 五年影响因子：2.876 ）

ISSN： 0920-1742

年卷期： 2019 年 45 卷 3 期

页码：

收录情况： SCI

摘要： In fish, as in mammals, several studies have demonstrated that the cocaine- and amphetamine-regulated transcript (CART) plays an important role in feeding. However, thus far, the function of CART in gibel carp (Carassius auratus gibelio) feeding regulation has not been reported. In our study, we first identified three forms of CART peptide precursors from gibel carp brain and named these CART-1, CART-2, and CART-3. The full-length cDNA sequences of CART-1, CART-2, and CART-3 were 616bp, 705bp, and 760bp, respectively, encoding peptides of 118, 120, and 104 amino acid residues. We detected mRNA expression of CART-1, CART-2, and CART-3 in a wide range of peripheral and central tissues, with the highest expression detected in the brain. After a meal, mRNA expression of CART-1, CART-2, and CART-3 was significantly elevated, suggesting that CART-1, CART-2, and CART-3 may act as postprandial satiety signals. Moreover, mRNA expression of all three CART-1, CART-2, and CART-3 was significantly reduced during fasting and significantly elevated with refeeding. Our findings indicate that CART-1, CART-2, and CART-3 might function as a satiety factor in the gibel carp.

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