Antibacterial Radicicol Analogues from Pochonia chlamydosporia and Their Biosynthetic Gene Cluster

文献类型： 外文期刊

第一作者： Qin, Feifei

作者： Qin, Feifei;Lin, Runmao;Zhang, Xi;Du, Shushan;Cheng, Xinyue;Qin, Feifei;Li, Yan;Lin, Runmao;Zhang, Xi;Mao, Zhenchuan;Ling, Jian;Yang, Yuhong;Zhuang, Xia;Xie, Bingyan

作者机构：

关键词： Pochonia chlamydosporia; radicicol analogues; antibacterial activity; Xanthomonas campestris pv. campestris; biosynthetic gene cluster

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2019 年 67 卷 26 期

页码：

收录情况： SCI

摘要： Chemical investigation of fungus Pochonia chlamydosporia strain 170, derived from rice fermentation sediment samples, afforded seven radicicol analogues, including two new compounds, monocillin VI (1) and monocillin VII (2), and five known compounds, monocillin II (3), monorden D (4), monocillin IV (5), monocillin V (6), and pochonin M (7). The structures of compounds 1-7 were established primarily by analysis of nuclear magnetic resonance data, and the absolute configurations of the secondary alcohol in compounds 1 and 2 were assigned by the modified Mosher method. All seven compounds have modest antibacterial activities, with a minimal inhibitory concentration (MIC) of 25.6 mu g/mL for compounds 1 and 3-7 and 51.2 mu g/mL for compound 2, on inhibition of the growth of the plant pathogen Xanthomonas campestris (the positive control ampicillin showed a MIC value of 12.8 mu g/mL), indicating that the fungus has the potential to control bacterial disease. The biosynthetic gene cluster and putative biosynthetic pathways of these radicicol analogues in the P. chlamydosporia genome were proposed. These findings increase our knowledge of the chemical potential of P. chlamydosporia and may allow us to better utilize the fungus as a biological control agent.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序