Activin β Is Critical for Larval-Pupal Transition in the 28 Spotted Lady Beetle Henosepilachna vigintioctopunctata

文献类型： 外文期刊

第一作者： Fu, Kai-Yun

作者： Fu, Kai-Yun;Fu, Kai-Yun;Chen, Feng;Jin, Lin;Li, Guo-Qing

作者机构：

关键词： activin beta; baboon isoform; Henosepilachna vigintioctopunctata; metamorphosis; pigmentation

期刊名称：ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：1.9； 五年影响因子：2.2 ）

ISSN： 0739-4462

年卷期： 2025 年 118 卷 1 期

页码：

收录情况： SCI

摘要： The activin cascade is activated when a pair of extracellular ligand (Myoglianin, Myo; Activin beta, Act beta; Dawdle, Daw) binds to two pairs of transforming growth factor beta (TGF) serine-threonine receptor kinases, TGF-beta type I (Baboon, Babo) and II receptors. However, the roles of activin way have not well been explored in non-Drosophilid insects. In the present paper, we compared the functions of Activin beta (Act beta) ligand and receptor isoform BaboB in post-embryonic development in a defoliating ladybird Henosepilachna vigintioctopunctata. RNA interference (RNAi) for Hvact beta but not Hvbabob upregulated juvenile hormone signal, reduced ecdysone pathway and impaired larval-pupal transformation. The arresting Hvact beta RNAi larvae formed pupa-specific black markings below the larval exuviae. Thus, the impairment of metamorphosis may be caused by failing to complete ecdysis behavior due to nonfunctional muscles. Consistently, larval body sizes were smaller and adult appendages were shorter in the Hvact beta RNAi larvae, in contrast to those in the Hvbabob depleted beetles. Conversely, knockdown of Hvbabob but not Hvact beta changed the pigmentation of adult elytra. Our results suggest that Act beta exerts regulative roles in JH production, ecdysteroidogenesis and organ remodeling, thus contributing to modulate the larva-pupa-adult transformation, through a BaboB independent way in H. vigintioctopunctata.

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