Intragenic Recombination as a Mechanism of Genetic Diversity in Bluetongue Virus

文献类型： 外文期刊

第一作者： He, Cheng-Qiang

作者： He, Cheng-Qiang;Ding, Nai-Zheng;He, Mei;Li, Shan-Ni;Wang, Xing-Ming;Liu, Xin-Fa;Guo, Hong-Shan;He, Cheng-Qiang;He, Hong-Bin

作者机构：

期刊名称：JOURNAL OF VIROLOGY （ 影响因子：5.103； 五年影响因子：5.078 ）

ISSN： 0022-538X

年卷期： 2010 年 84 卷 21 期

页码：

收录情况： SCI

摘要： Bluetongue (BT), caused by Bluetongue virus (BTV), is an economically important disease affecting sheep, deer, cattle, and goats. Since 1998, a series of BT outbreaks have spread across much of southern and central Europe. To study why the epidemiology of the virus happens to change, it is important to fully know the mechanisms resulting in its genetic diversity. Gene mutation and segment reassortment have been considered as the key forces driving the evolution of BTV. However, it is still unknown whether intragenic recombination can occur and contribute to the process in the virus. We present here several BTV groups containing mosaic genes to reveal that intragenic recombination can take place between the virus strains and play a potential role in bringing novel BTV lineages.

分类号： Q934.2

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