The synergistic effect of epigallocatechin-3-gallate and quercetin co-loaded hydrogel beads on inflammatory bowel disease

文献类型： 外文期刊

第一作者： Hu, Miao

作者： Hu, Miao;Du, Xiaoqian;Liu, Guannan;Qi, Baokun;Li, Yang;Hu, Miao;Huang, Yuyang

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）

ISSN： 2042-6496

年卷期： 2023 年 14 卷 10 期

页码：

收录情况： SCI

摘要： The synergistic effect of epigallocatechin-3-gallate (E) and quercetin (Q) enhances the therapeutic efficacy on related diseases; however, the instability and lower bioavailability of E and Q limited their application. Therefore, E and Q were co-encapsulated in hydrogel beads (H) with sodium alginate (SA) and soybean protein isolate (SPI) to improve their stability and bioavailability. The anti-inflammatory effect and molecular mechanism of action of E and Q co-loaded H in inflammatory bowel disease (IBD) were also investigated. The results showed that EQH-treated macrophages produced the lowest NO and TNF-alpha at 18.64 mu mol L-1 and 5855.25 ng mL(-1), respectively. The protein expression of p-NF kappa B-p65 was the lowest in EQH, indicating that EQH inhibits the activation of the pro-inflammatory NF-kappa B signaling pathway. The colon length of IBD model rats fed EH, QH, and EQH increased; histological analysis revealed intact layers of colonic epithelial cells with no observable tissue damage. The TNF-a and IL-1 beta levels in the plasma of the EQH-treated rats decreased, indicating the inhibition of the TLR4 and NF-kappa B signaling pathways, and Q's level in the colon was the highest at 0.04 mg mL(-1). This study provides a theoretical basis for the application of E and Q in IBD.

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