A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus

文献类型： 外文期刊

第一作者： Liu, Peng

作者： Liu, Peng;Liu, Shuang;Lei, Jiajia;Lu, Qisen;Hu, Haichao;Chen, Lu;Jiang, Yaoyao;Feng, Lixiao;Zhang, Tianye;Zhong, Kaili;Liu, Jiaqian;Zhang, Juan;Chen, Jianping;Yang, Jian;Shi, Chaonan;Ren, Yan;Zhang, Ning;Sun, Congwei;Sun, Bingjian;Chen, Feng;Zhang, Zhuo;Tang, Yimiao

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）

ISSN：

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Wheat yellow mosaic virus (WYMV), a soil-borne pathogen, poses a serious threat to global wheat production. Here, we identify a WYMV resistance gene, TaRD21A, that belongs to the papain-like cysteine protease family. Through genetic manipulation of TaRD21A expression, we establish its positive role in the regulation of wheat to WYMV resistance. Furthermore, our investigation shows that the TaRD21A-mediated plant antiviral response relies on the release of a small peptide catalyzed by TaRD21A protease activity. To counteract wheat resistance, WYMV-encoded nuclear inclusion protease-a (NIa) suppress TaRD21A activity to promote virus infection. In resistant cultivars, a natural variant of TaRD21A features a alanine to serine substitution and this substitution enables the phosphorylation of Serine, thereby weakening the interaction between NIa and TaRD21A, reinforcing wheat resistance against WYMV. Our study not only unveils a WYMV resistance gene but also offers insights into the intricate mechanisms underpinning resistance against WYMV. Soil-borne wheat yellow mosaic virus (WYMV) poses a serious threat to global wheat production. Here, the authors report that the nuclear inclusion protease-a produced by WYMV interacts with a small peptide catalyzed by TaRD21A protease activity to mediate WYMV resistance through activating MAPK signaling pathway.

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