A New Polyketide Derivative from the Nicotiana tabacum Symbiotic Fungus Aspergillus japonicus TE-739D

文献类型： 外文期刊

第一作者： Wang, Haisu

作者： Wang, Haisu;Zhang, Peng;Gu, Gan;Gao, Renji;Zhan, Lei;Liu, Xijin;Bai, Xiaojie;Jiang, Long

作者机构：

关键词： Secondary metabolites; Aspergillus japonicus; polyketides; antibacterial activity. (c) 2025 ACG Publications. All rights reserved

期刊名称：RECORDS OF NATURAL PRODUCTS （ 影响因子：1.6； 五年影响因子：1.4 ）

ISSN： 1307-6167

年卷期： 2025 年 19 卷 5 期

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收录情况： SCI

摘要： Filamentous fungi are very well known for producing a wide variety of secondary metabolites with important biological effects. In our study chemical exploration of the Nicotiana tabacum symbiotic fungus Aspergillus japonicus TE-739D led to the discovery of a new polyketide derivative, namely (3S,4E,6E,9S)-9hydroxy-3,7-dimethyldeca-4,6-dienoic acid (1), along with three previously reported compounds 2-4. The structures of these compounds were elucidated by using HRESIMS, NMR spectroscopic analyses, and quantum chemical calculations. Compounds 3 and 4 showed strong antibacterial activity against four representative bacterial strains including two Gram-negative species (Agrobacterium tumefaciens and Xanthomonas oryzae) and two Gram-positive Bacillus species (B. cereus and B. subtilis), with MIC values range from 1 to 16 mu g/mL, respectively.

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