Immunocompetent rabbits infected with Cryptosporidium cuniculus as an animal model for anti-cryptosporidial drug testing

文献类型： 外文期刊

第一作者： Lu, Chunxia

作者： Lu, Chunxia;Liu, Xianyong;Liu, Jie;Suo, Xun;Tang, Xinming;Zhu, Guan;Striepen, Boris

作者机构：

关键词： Cryptosporidium cuniculus; Cryptosporidiosis; Animal model; Drug efficacy

期刊名称：INTERNATIONAL JOURNAL FOR PARASITOLOGY （ 影响因子：4.33； 五年影响因子：4.388 ）

ISSN： 0020-7519

年卷期： 2022 年 52 卷 4 期

页码：

收录情况： SCI

摘要： Cryptosporidium is one of the leading causes of diarrheal disease in humans and animals, which can be severe and deadly in neonates and immunocompromised hosts. Studies on the biology of Cryptosporidium and drug discovery efforts have been hindered by a number of factors including the lim-ited availability of animal models. Here, we report the establishment and characterization of an immuno-competent rabbit model for infection with Cryptosporidium cuniculus. By testing four known anti-cryptosporidial compounds (nitazoxanide, baicalein, curcumin and matrine), we showed that the rabbit could be used as an alternative animal model for evaluating anti-cryptosporidial drug efficacy in vivo. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of Australian Society for Parasitology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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