Analyses of circRNAs profiles of the lactating and nonlactating crops in pigeon (Columba livia)

文献类型： 外文期刊

第一作者： Ma, Hui

作者： Ma, Hui;Bian, Shixiong;Li, Yunlei;Ni, Aixin;Zhang, Ran;Ge, Pingzhuang;Wang, Yuanmei;Zhao, Jinmeng;Zong, Yunhe;Yuan, Jingwei;Sun, Yanyan;Chen, Jilan;Han, Pengmin

作者机构：

关键词： circRNAs; ceRNAs; crop milk; lactation; pigeon

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2023 年 102 卷 3 期

页码：

收录情况： SCI

摘要： Pigeon has the specific biological ability to produce pigeon milk (also known as crop milk) by its crop. Circular RNAs (circRNAs) are important non -coding RNAs acting as the sponges of miRNAs, but the molecular mechanism of circRNAs regulating crop milk production has not been reported in pigeon. We com-pared expression profiles of crops during lactating and nonlactating crops, and networks of competing endoge-nous RNAs (ceRNAs) were constructed. The results showed a total of 8,723 circRNAs were identified, and there were 770 differentially expressed circRNAs (DECs) between these two different periods of crops. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that the host genes of DECs were enriched in GnRH, MAPK, Insulin, Wnt, and AMPK signaling pathways. Further-more, gga_circ_0000300 interacted with miR-92-2-5p, which targeted genes participating in lactation and milk composition synthesis. Gga_circ_0003018, gga_-circ_0003019 and gga_circ_0003020 could bind with let-7c-5p regulating SOCS3 in crop milk production. These findings provide the circRNAs expression profiles and facilitate the analysis of molecular mechanism of crop milk production in pigeon.

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