Preparation of ceftiofur-encapsulated hen-egg low-density lipoproteins and their antibacterial effects on intracellular Staphylococcus aureus

文献类型： 外文期刊

第一作者： Zhao, Yi

作者： Zhao, Yi;Mao, Wei;Liu, Bo;Wang, Yong-fei;Zhang, Shuang-yi;Guo, Li-li;Gong, Zhi-guo;Zhao, Jia-min;Yang, Xiao-lin;Qu, Gang-gang;Hasi, Su-rong;Bai, Yu-ting;Cao, Jin-shan;Zhao, Yi;Mao, Wei;Liu, Bo;Wang, Yong-fei;Zhang, Shuang-yi;Guo, Li-li;Gong, Zhi-guo;Zhao, Jia-min;Yang, Xiao-lin;Qu, Gang-gang;Bai, Yu-ting;Cao, Jin-shan;Wang, Yong-fei;Qian, Ying-hong

作者机构：

关键词： Hen-egg low-density lipoprotein; Ceftiofur; Intracellular drug delivery system; Staphylococcus aureus

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2024 年 278 卷

页码：

收录情况： SCI

摘要： Hen egg low-density lipoprotein (heLDL), as alternative of serum-derived LDL, was used as drug delivery system of ceftiofur (CEF). The CEF-loaded hen egg low-density lipoprotein (CEF-heLDL) with complete apolipoprotein structure and high drug loading rate was synthesized, possesses suitable particle size. CEF-heLDL undergoes cellular uptake and colocalizes with lysosomes in vitro. An intracellular infection model of the bovine endometrial epithelial cells and a coeliac-induced inflammation model of mice by Staphylococcus aureus (S. aureus) were established, and significantly lower intracellular S. aureus levels of CEF-heLDL group than CEF-free group (P < 0.001) was observed. The antibacterial efficacy was sustained for 24 h. Up to 400 mg/kg of CEF-heLDL, 20 times the clinical practice, were intraperitoneally administrated, and no significant toxicity signs on mice were observed. HeLDLs is an effective, safe, and cheap drug carrier, and could also be used for transmembrane delivering other antibiotics.

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