Self-Assembly System Based on Cyclodextrin for Targeted Delivery of Cannabidiol

文献类型： 外文期刊

第一作者： Zhu, Panyong

作者： Zhu, Panyong;Lv, Pin;Zhang, Yazhou;Liao, Xiali;Gao, Chuanzhu;Yang, Bo;Lv, Pin;Guo, Rong;Chen, Xuan;Yang, Ming;Liao, Rongqiang;Liu, Jing;Zhang, Kun

作者机构：

关键词： biotin; ss-cyclodextrin; cannabidiol; inclusion complex; targeting delivery; self-assembly

期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.221； 五年影响因子：5.385 ）

ISSN： 2296-2646

年卷期： 2021 年 9 卷

页码：

收录情况： SCI

摘要： Cannabidiol (CBD) is one specific kind of the cannabinoid in Cannabis sativa L with a wide range of pharmacological activities. However, the poor water solubility and specificity of CBD limits its application in pharmaceutical field. For solving these problems, in this work, we successfully prepared a targeted carrier by grafting biotin (BIO) onto ethylenediamine-beta-Cyclodextrin (EN-CD) in a single step to generate a functionalized supramolecule, named BIO-CD. Subsequently, an amantadine-conjugated cannabinoids (AD-CBD) was prepared and self-assembled with the BIO-CD. A series of methods were used to characterize the inclusion behavior and physicochemical properties of AD-CBD and BIO-CD. The results showed that AD-CBD entered the cavity of BIO-CD and formed a 1:1 host-guest inclusion complex. MTT assay and confocal laser scanning microscopy (CLSM) revealed that the targeting effect and anticancer activity of AD-CBD/BIO-CD inclusion complex against three human cancer cell lines were higher than BIO-CD, AD-CBD and free CBD. Moreover, the inclusion complex could release drugs under weakly acidic conditions. These results demonstrated that AD-CBD/BIO-CD inclusion complex possess excellent targeted and anticancer activity, which is hopeful to be applied in clinic as a new therapeutic approach.

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