Untargeted Metabolomics Reveals the Metabolic Characteristics and Biomarkers of Antioxidant Properties of Gardeniae Fructus from Different Geographical Origins in China

文献类型： 外文期刊

第一作者： Jiang, Wu

作者： Jiang, Wu;Duan, Xiaojing;Chen, Jiadong;Liu, Yingying;Tao, Zhengming;Jiang, Wu;Duan, Xiaojing;Chen, Jiadong;Liu, Yingying;Tao, Zhengming;Jiang, Lingling;Jiang, Lingling;Yin, Xiaoli;Zhang, Shuhui;Zheng, Hong

作者机构：

关键词： antioxidant; biomarker; metabolomics; flavonoids; geographical origin

期刊名称：METABOLITES （ 影响因子：3.7； 五年影响因子：4.1 ）

ISSN：

年卷期： 2025 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Background/Objectives: Gardeniae Fructus (GF) has been widely used as both food and medicinal purposes for thousands of years, but their antioxidant properties and potential metabolite biomarkers remain unclear. Methods: The purposes of this study were to examine antioxidant activities of 21 GF varieties from different geographical origins in China and identify potential biomarkers of antioxidant properties using an untargeted LC-MS-based metabolomics approach. Results: The results demonstrate that metabolomics had the ability to trace the geographical origins of GF. We found that antioxidant activities varied with different varieties of GF, which was dependent on their chemical compositions. The key chemical categories were obtained as the primary contributors of the antioxidant activity, including prenol lipids, flavonoids, coumarins and derivatives, as well as steroids and steroid derivatives. In addition, adouetine Y, coagulin R 3-glucoside and epicatechin 3-glucoside were identified as potential biomarkers for the antioxidant activity of GF. Conclusions: Therefore, our study sheds light on the metabolic characteristics and biomarkers of the antioxidant properties of GF, contributing to the selection and cultivation of a high antioxidant variety.

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