Characterization of Conserved Evolution in H7N9 Avian Influenza Virus Prior Mass Vaccination

文献类型： 外文期刊

第一作者： He, Dongchang

作者： He, Dongchang;Wang, Xiyue;Wu, Huiguang;Cai, Kairui;Wang, Xiaoquan;Hu, Jiao;Hu, Shunlin;Liu, Xiaowen;Peng, Daxin;Gu, Min;Liu, Xiufan;He, Dongchang;Song, Xiaoli;Wang, Xiaoquan;Hu, Jiao;Hu, Shunlin;Liu, Xiaowen;Ding, Chan;Peng, Daxin;Gu, Min;Liu, Xiufan;Wang, Xiaoquan;Hu, Jiao;Hu, Shunlin;Liu, Xiaowen;Peng, Daxin;Gu, Min;Liu, Xiufan;Ding, Chan;Su, Shuo

作者机构：

关键词： Avian influenza; evolution; vaccination; elimination

期刊名称：VIRULENCE （ 影响因子：5.4； 五年影响因子：5.7 ）

ISSN： 2150-5594

年卷期： 2024 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Vaccination is crucial for the prevention and mitigation of avian influenza infections in China. The inactivated H7N9 vaccine, when administered to poultry, significantly lowers the risk of infection among both poultry and humans, while also markedly decreasing the prevalence of H7N9 detections. Highly pathogenic (HP) H7N9 viruses occasionally appear, whereas their low pathogenicity (LP) counterparts have been scarcely detected since 2018. However, these contributing factors remain poorly understood. We conducted an exploratory investigation of the mechanics via the application of comprehensive bioinformatic approaches. We delineated the Yangtze River Delta (YRD) H7N9 lineage into 5 clades (YRD-A to E). Our findings highlight the emergence and peak occurrence of the LP H7N9-containing YRD-E clade during the 5th epidemic wave in China's primary poultry farming areas. A more effective control of LP H7N9 through vaccination was observed compared to that of its HP H7N9 counterpart. YRD-E exhibited a tardy evolutionary trajectory, denoted by the conservation of its genetic and antigenic variation. Our analysis of YRD-E revealed only minimal amino acid substitutions along its phylogenetic tree and a few selective sweep mutations since 2016. In terms of epidemic fitness, the YRD-E was measured to be lower than that of the HP variants. Collectively, these findings underscore the conserved evolutionary patterns distinguishing the YRD-E. Given the conservation presented in its evolutionary patterns, the YRD-E LP H7N9 is hypothesized to be associated with a reduction following the mass vaccination in a relatively short period owing to its lower probability of antigenic variation that might affect vaccine efficiency.

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