Targeted and non-targeted metabolic characteristics of 6,7-dihydroxy-2,4-dimethoxyphenanthrene during simulated gastrointestinal digestion

文献类型： 外文期刊

第一作者： Li, Qian

作者： Li, Qian;Liu, Fan;Liao, Sentai;Zhou, Donglai;Xing, Dongxu;Zou, Yuxiao

作者机构：

关键词： Phenanthrenes; Chinese yam; Gastrointestinal digestion; Characteristic metabolism

期刊名称：FOOD CHEMISTRY （ 影响因子：9.8； 五年影响因子：9.7 ）

ISSN： 0308-8146

年卷期： 2025 年 464 卷

页码：

收录情况： SCI

摘要： 6,7-dihydroxy-2,4-dimethoxyphenanthrene (PC4), isolated and identified from Chinese yam, was one of the important characteristic active ingredients. The present study established simulated gastrointestinal digestion and caco-2 intestinal epithelial models to investigate the digestive and metabolic characteristics of PC4. The results indicated that PC4 was mainly digested and metabolized in the intestine, with a digestion rate of 94 %, producing active characteristic metabolites including 2,6-dimethoxy-4-phenanthrenol (MC1) and 1-methoxyphenanthrene (MC2). Molecular docking indicated that the COX-2 enzyme inhibitory activity of MC1 might be superior to that of the prototype PC4. During 24 h co-incubation of PC4 with caco-2 monolayer epithelial, the signal pathway related to lipid decomposition was up-regulated within 0-12 h, while the diabetes complications AGE-RAGE was inhibited just in 0-6 h period significantly. The research database provided scientific basis for the digestion and metabolism of PC4, and laid theoretical foundation for the scientific development of Chinese yam functional foods.

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