T-Cell Epitope-Based Vaccines: A Promising Strategy for Prevention of Infectious Diseases

文献类型： 外文期刊

第一作者： Song, Xin

作者： Song, Xin;Li, Yongfeng;Wu, Hongxia;Qiu, Huaji;Sun, Yuan

作者机构：

关键词： T-cell epitopes; cell-mediated immune responses; epitope identification; vaccines; infectious diseases

期刊名称：VACCINES （ 影响因子：3.4； 五年影响因子：3.7 ）

ISSN：

年卷期： 2024 年 12 卷 10 期

页码：

收录情况： SCI

摘要： With the development of novel vaccine strategies, T-cell epitope-based vaccines have become promising prophylactic and therapeutic tools against infectious diseases that cannot be controlled via traditional vaccines. T-cell epitope-based vaccines leverage specific immunogenic peptides to elicit protective T-cell responses against infectious pathogens. Compared to traditional vaccines, they provide superior efficacy and safety, minimizing the risk of adverse side effects. In this review, we summarized and compared the prediction and identification methods of T-cell epitopes. By integrating bioinformatic prediction and experimental validation, efficient and precise screening of T-cell epitopes can be achieved. Importantly, we delved into the development approaches to diverse T-cell epitope-based vaccines, comparing their merits and demerits, as well as discussing the prevalent challenges and perspectives in their applications. This review offers fresh perspectives for the formulation of safe and efficacious epitope-based vaccines for the devastating diseases against which no vaccines are currently available.

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