Plant-derived strategies to fight against severe acute respiratory syndrome coronavirus 2

文献类型： 外文期刊

第一作者： Li, Wenkang

作者： Li, Wenkang;Ding, Tianze;Chang, Huimin;Peng, Yuanchang;Li, Jun;Liang, Xin;Ma, Huixin;Li, Fuguang;Ren, Maozhi;Wang, Wenjing;Li, Wenkang;Ding, Tianze;Chang, Huimin;Peng, Yuanchang;Li, Jun;Liang, Xin;Ma, Huixin;Li, Fuguang;Ren, Maozhi;Wang, Wenjing;Liang, Xin;Li, Fuguang;Wang, Wenjing;Ren, Maozhi;Wang, Wenjing

作者机构：

关键词： SARS-CoV-2; Plant natural products; Antiviral drugs; Molecular farming; Structural biology; Synthetic biology

期刊名称：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY （ 影响因子：6.7； 五年影响因子：6.5 ）

ISSN： 0223-5234

年卷期： 2024 年 264 卷

页码：

收录情况： SCI

摘要： The coronavirus disease 2019 (COVID-19) pandemic has caused an unprecedented crisis, which has been exacerbated because specific drugs and treatments have not yet been developed. In the post-pandemic era, humans and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) will remain in equilibrium for a long time. Therefore, we still need to be vigilant against mutated SARS-CoV-2 variants and other emerging human viruses. Plant-derived products are increasingly important in the fight against the pandemic, but a comprehensive review is lacking. This review describes plant-based strategies centered on key biological processes, such as SARS-CoV-2 transmission, entry, replication, and immune interference. We highlight the mechanisms and effects of these plant-derived products and their feasibility and limitations for the treatment and prevention of COVID-19. The development of emerging technologies is driving plants to become production platforms for various antiviral products, improving their medicinal potential. We believe that plant-based strategies will be an important part of the solutions for future pandemics.

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