High-Gravity-Facilitated Facile Preparation of a Pyraclostrobin Nanocapsule Suspension for Enhanced Foliar Adhesion, Antifungal Activity, and Biosafety

文献类型： 外文期刊

第一作者： Fan, Rongrong

作者： Fan, Rongrong;Hao, Zhongqian;Wei, Wenyi;Wang, Jie-Xin;Wang, Dan;Le, Yuan;Chen, Jian-Feng;Fan, Rongrong;Hao, Zhongqian;Wei, Wenyi;Wang, Jie-Xin;Wang, Dan;Le, Yuan;Chen, Jian-Feng;Zheng, Hanfei

作者机构：

期刊名称：INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH （ 影响因子：3.9； 五年影响因子：4.0 ）

ISSN： 0888-5885

年卷期： 2025 年 64 卷 35 期

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收录情况： SCI

摘要： The increasing demand for enhanced pesticide utilization efficiency while ensuring biosafety and minimizing environmental risks has prompted the development of eco-friendly and sustainable nanoformulations. Herein, a pyraclostrobin-loaded polylactic acid nanocapsule suspension (Pyr@PLA NCS) was prepared using high-gravity technology in a rotating packed bed, yielding monodisperse spherical nanocapsules with an average size of 133.3 +/- 1.4 nm (PDI = 0.167 +/- 0.008) and a high encapsulation efficiency (97.9 +/- 0.7%). The Pyr@PLA NCS demonstrated long-term storage stability, improved UV resistance, and sustained release properties, thereby significantly extending the effective duration of pyraclostrobin. Notably, the nanoformulation improved foliage wettability, adhesion, and retention and exhibited uniform deposition and a strong affinity for leaves. Biological assays revealed that Pyr@PLA NCS significantly enhanced antifungal activity against Botrytis cinerea and showed persistent control efficacy. Biosafety assessment indicated that the nanoformulation exhibited a 97.1-fold reduction in acute zebrafish toxicity compared to technical pyraclostrobin and a good plant safety profile. This study presented a scalable, green nanocapsule formulation with high agricultural applicability and provided a facile continuous manufacturing strategy for sustainable nanopesticide formulation production.

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