Dimeric Tetracenomycin Derivatives from a Taklamakan Desert-Derived Streptomyces sp. HDN154193
文献类型： 外文期刊
第一作者： Xing, Li
作者： Xing, Li;Chang, Yimin;Zhang, Xiaoqian;Hou, Xuewen;Han, Yaxin;Zhu, Tianjiao;Zhang, Guojian;Che, Qian;Li, Dehai;Shah, Mudassir;Shah, Mudassir;Peng, Jixing;Zhang, Guojian;Li, Dehai
作者机构：
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.803； 五年影响因子：4.869 ）
ISSN： 0163-3864
年卷期： 2022 年 85 卷 1 期
页码：
收录情况： SCI
摘要： Bitetracenomycin A (1) and its diastereomers [(+/-)-bitetracenomycin B, (+/-)-2] were discovered from the cultures of Streptomyces sp. HDN154193. Compounds 1 and (+/-)-2 were the first tetracenomycin dimers obtained from a natural source with sp(3) methine protons at the bridge positions (C-12/12'), which also exhibited broad-spectrum antibacterial activity. The racemate (+/-)-2 was semisynthesized and separated into enantiomers (+)-2 and (-)-2, and the absolute configurations were determined by specific rotation and ECD data. These metabolites exhibited potent antibacterial activity especially against drug-resistant strains (MRSA and MRCNS) with MIC values ranging from 1.0 to 1.9 mu g/mL.
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