Jellyfish-Inspired Artificial Spider Silk for Luminous Surgical Sutures

文献类型： 外文期刊

第一作者： Wen, Kai

作者： Wen, Kai;Zhang, Guanghao;Wang, Meilin;Mei, Guangkai;Zhao, Weiqiang;Guo, Wenjin;Wang, Wei;Liu, Zunfeng;Zhang, Chao;Zhou, Xiang;Zhang, Guanghao;Bai, Jie;Zhou, Xiang;Zhang, Zhenzhen;Zhou, Qiang;Liu, Enzhao;Zhu, Yutian;Zhu, Meifang

作者机构：

关键词： "sheath-core" architecture; aggregation-induced luminescence; biomimetic; luminous fibers; surgical sutures

期刊名称：ADVANCED MATERIALS （ 影响因子：27.4； 五年影响因子：30.2 ）

ISSN： 0935-9648

年卷期： 2024 年

页码：

收录情况： SCI

摘要： The development of functional surgical sutures with excellent mechanical properties, good fluorescence, and high cytocompatibility is highly required in the field of medical surgeries. Achieving fibers that simultaneously exhibit high mechanical robustness, good spinnability, and durable fluorescence emission has remained challenging up to now. Taking inspiration from the spinning process of spider silk and the luminescence mechanism of jellyfish, this work reports a luminous artificial spider silk prepared with the aim of balancing the fiber spinnability and mechanical robustness. This is realized by employing highly hydrated segments with aggregation-induced luminescence for enhancing the fiber spinnability and polyhydroxyl segments for increasing the fiber mechanical robustness. Twist insertion during fiber spinning improves the fiber strength, toughness, and fluorescence emission. Furthermore, coating the fiber with an additional polymer layer results in a "sheath-core" architecture with improved mechanical properties and capacity to withstand water. This work provides a new design strategy for performing luminescent and robust surgical sutures. Taking inspiration from the spinning process of spider silk and the luminescence mechanism of jellyfish, the luminous artificial spider silks are prepared by employing highly hydrated segments and polyhydroxyl segments. Furthermore, a luminescent surgical suture is prepared by coating the fiber with an additional polymer layer. This work provides a new design strategy for performing luminescent and robust surgical sutures. image

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