Regulation of the developmental programs in Toxoplasma by a novel SNF2L-containing chromatin remodeling complex

文献类型： 外文期刊

第一作者： Zhu, Yuchao

作者： Zhu, Yuchao;Fan, Bolin;Xu, Hao;Li, Yazhou;Liang, Xiaohan;Xue, Lilan;Wei, Liting;Fan, Fuqiang;Zhang, Xin;Chen, Yukun;Shen, Bang;Zhu, Yuchao;Fan, Bolin;Xu, Hao;Li, Yazhou;Liang, Xiaohan;Xue, Lilan;Wei, Liting;Fan, Fuqiang;Zhang, Xin;Chen, Yukun;Shen, Bang;Qian, Shanshan;Shen, Bang;Shen, Bang

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

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收录情况： SCI

摘要： Toxoplasma gondii is an extremely successful parasite infecting one third of the human population and numerous animals. It has a complex life cycle with multiple developmental stages that are key for its transmission and pathogenesis. But how the developmental programs are regulated is largely unknown. Here, we screen putative chromatin remodeling proteins in T. gondii and find that a novel complex containing an evolutionarily conserved ATPase SNF2L is critical for programming the parasite's development. This complex contains four core proteins and conditional depletion of three of them leads to similar expression changes of developmentally regulated genes, including increased transcription of genes involved in sexual commitment and development. Accordingly, depletion of SNF2L causes merogony and out-budding types of division, which are otherwise only observed at the enteroepithelial stages within definitive hosts where sexual reproduction of the parasite occurs. After being recruited to target regions, SNF2L regulates gene expression by modulating local chromatin accessibility or by recruiting accessory proteins to its binding sites, thus ensuring that the gene expression and reproduction patterns are matched to the life cycle stages. Conditional depletion of SNF2L offers an opportunity to study the unique biology of the parasite during pre-sexual and sexual developments in vitro.

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