A novel controlled-release Zn2+ supplementation based on egg yolk phosvitin: Structural, physicochemical and release characteristics

文献类型： 外文期刊

第一作者： Liu, Yuanjing

作者： Liu, Yuanjing;Zeng, Shaodong;Chen, Wuhai;Ye, Jianzhi;Dong, Mengxue;Sun, Yusha;Duan, Xiang

作者机构：

关键词： Zinc supplementation; Release controllability; Phosvitin; Metal chelation

期刊名称：LWT-FOOD SCIENCE AND TECHNOLOGY （ 影响因子：6.6； 五年影响因子：6.9 ）

ISSN： 0023-6438

年卷期： 2025 年 220 卷

页码：

收录情况： SCI

摘要： Zinc supplements are a common remedy for zinc dysregulation, and the controllable-release characteristic is important for preventing gastric mucosal damage and improving zinc bioavailability. In this work, egg-derived phosvitin, the most highly phosphorylated protein in nature, was used to prepare a Zn-chelating system to control Zn2+ release process in gastrointestinal tract. The results showed that the PSV-Zn chelates were successfully prepared, with the maximum chelation rate of 66%. The UV spectrum, fluorescence spectroscopy, and infrared spectroscopy results suggested that Zn2+ mainly binds to phosphate groups and aromatic amino acids of PSV. The chelation reaction altered the original structure of PSV, leading to the aggregation of molecules and the changes in elemental composition in particle surface of PSV-Zn complex. The chelates exhibited synergistic antioxidant activities. Interestingly, the in vitro simulations showed that PSV-Zn chelates exhibited a low Zn2+ release rate in stomach and a good Zn2+ release property in small intestine. This meant that the PSV-Zn complex has good release controllability, and thus possesses a potential to protect gastric mucosa and improve zinc bioavailability in small intestine. Therefore, this work provides a theoretical reference for preparing novel controlled-release Zn2+ supplements based on functional proteins.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序