Design, synthesis, and biological activity of novel pomalidomide linked with diphenylcarbamide derivatives

文献类型： 外文期刊

第一作者： Liu, Xiaofei

作者： Liu, Xiaofei;Ji, Tao;Zhan, Xiaoguang;Mao, Longfei;Deng, Peng;Shi, Lin;Sun, Bin;Liu, Xiaofei;Ji, Tao;Zhan, Xiaoguang;Mao, Longfei

作者机构：

关键词： 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline1,3-dione; pomalidomide; diphenylcarbamide; derivatives; synthesis; IDO1

期刊名称：HETEROCYCLIC COMMUNICATIONS （ 影响因子：2.0； 五年影响因子：1.436 ）

ISSN： 0793-0283

年卷期： 2022 年 28 卷 1 期

页码：

收录情况： SCI

摘要： Based on 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione as a raw material, a series of novel pomalidomide linked with diphenylcarbamide derivatives were synthesized through several step reactions of substitution, click reaction, and addition reaction. The structures of these compounds were confirmed by H-1 NMR, C-13 NMR, and MS. We discovered that some of the compounds are capable of suppressing indoleamine pyrrole-2,3-dioxygenase-1 activities in in vitro experiments, in which the inhibitory activity of 5b reached the level of benefits.

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