Design, synthesis, and biological activity of novel pomalidomide linked with diphenylcarbamide derivatives
文献类型： 外文期刊
第一作者： Liu, Xiaofei
作者： Liu, Xiaofei;Ji, Tao;Zhan, Xiaoguang;Mao, Longfei;Deng, Peng;Shi, Lin;Sun, Bin;Liu, Xiaofei;Ji, Tao;Zhan, Xiaoguang;Mao, Longfei
作者机构：
关键词： 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline1,3-dione; pomalidomide; diphenylcarbamide; derivatives; synthesis; IDO1
期刊名称：HETEROCYCLIC COMMUNICATIONS （ 影响因子：2.0； 五年影响因子：1.436 ）
ISSN： 0793-0283
年卷期： 2022 年 28 卷 1 期
页码：
收录情况： SCI
摘要： Based on 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione as a raw material, a series of novel pomalidomide linked with diphenylcarbamide derivatives were synthesized through several step reactions of substitution, click reaction, and addition reaction. The structures of these compounds were confirmed by H-1 NMR, C-13 NMR, and MS. We discovered that some of the compounds are capable of suppressing indoleamine pyrrole-2,3-dioxygenase-1 activities in in vitro experiments, in which the inhibitory activity of 5b reached the level of benefits.
分类号：
- 相关文献
作者其他论文 更多>>
-
Molecular Marker-Assisted Breeding and Seed Production Techniques for Shenyou R3, a New Premium Aromatic Hybrid Japonica Rice
作者：Zhang, Anpeng;Zhang, Jianming;Cheng, Can;Niu, Fuan;Zhou, Jihua;Sun, Bin;Dai, Yuting;Xie, Kaizhen;Chu, Huangwei;Cao, Liming
关键词：hybrid japonica; Shenyou R3; premium aromatic type; molecular marker-assisted breeding; seed production techniques
-
Dietary Methionine Restriction Alleviates Cognitive Impairment in Alzheimer's Disease Mice via Sex-Dependent Modulation on Gut Microbiota and Tryptophan Metabolism: A Multiomics Analysis
作者：Zhang, Yuyu;Li, Yiju;Wang, Da;Pang, Jingxi;Sang, Haojie;Xi, Yujia;Liu, Zhigang;Liu, Tianqi;Shi, Lin;Pan, Fei;Li, Yiju;Liu, Zhigang
关键词：Alzheimer's disease; methionine restriction; sexual dimorphism; indole-3-propionic acid; peroxisome proliferator-activated receptor alpha; multiomics
-
Study of the hydraulic characteristics of an airfoil-shaped weir trough measurement and control integrated facility combined with numerical simulation
作者：Su, Peng;Sun, Bin;Zhang, Wenzheng;Lv, Mouchao;Qin, Jingtao;Zhang, Wenzheng;Lv, Mouchao;Qin, Jingtao;Sun, Bin
关键词：ANSYS fluent; hydraulic performance; inclined airfoil weir; irrigation water management; stage-discharge relationship
-
Insights into Molecular Mechanism of Secondary Xylem Rapid Growth in Salix psammophila
作者：Qiao, Hongxia;Wei, Dongshan;Li, Yingjie;Chao, Kairui;Yang, Haifeng;Qiao, Hongxia;Wang, Yunhan;Liu, Guiming;Zhang, Jiewei;Qiao, Hongxia;Wang, Yunhan;Liu, Guiming;Zhang, Jiewei;Wang, Yunhan;Shi, Lin;Wang, Ruiping;Yang, Yeru;Jia, Li;Yu, Fengqiang
关键词：
Salix psammophila ; secondary growth; secondary xylem; lignin; caffeoyl shikimate esterase -
Unraveling the biofilm armor: How ROS drives biofilm formation in aquatic pathogen Edwardsiella piscicida
作者：Fang, Qingjian;Li, Chenghua;Fang, Qingjian;Gou, Yin;Gu, Hanjie;Wu, Qingjuan;He, Jiaojiao;Hu, Yonghua;Hu, Yonghua;Sun, Bin;Gu, Hanjie;Hu, Yonghua
关键词：Edwardsiella piscicida; Biofilm formation; Regulatory pathway; Oxidative stress; Virulence
-
Molecular Marker-Assisted Breeding of High-Quality and Salt-Tolerant Hybrid Japonica Rice Combination Shenyanyou 1
作者：Niu, Fuan;Zhang, Anpeng;Cheng, Can;Chu, Huangwei;Fang, Jun;Zhou, Jihua;Sun, Bin;Dai, Yuting;Zhang, Jianming;Feng, Zhizun;Cao, Liming
关键词：hybrid japonica rice; Shenyanyou 1; salt tolerance; high-quality; molecular marker-assisted breeding
-
TEMPO-oxidized cellulose nanofiber incorporating hydrophobic TA-HBPSi nanoparticles aerogels for efficient adsorption of fungicides in water
作者：Shao, Xiaolan;Chen, Hong;Zheng, Qianqi;Tu, Dingdi;Yan, Bei;Liu, Xiangying;Bai, Lianyang;Liu, Kailin;Shao, Xiaolan;Bai, Lianyang;Liu, Kailin;Deng, Peng;Li, Hui;Dai, Jinfeng
关键词：TA-HBPSi@TOCNF aerogel; Imazalil; DFT calculation
