文献类型： 外文期刊
第一作者： Cao, Xi
作者： Cao, Xi;Cai, Caihong;Yuan, Jingzhe;Gai, Cuijuan;Dai, Haofu;Wang, Pei;Mei, Wenli;Cao, Xi;Guo, Lei;Kong, Fandong
作者机构：
关键词： mangrove-derived fungus; Cladosporium sp.; metabolites; cytotoxicity; a; -glycosidase inhibitor
期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.545； 五年影响因子：5.869 ）
ISSN： 2296-2646
年卷期： 2021 年 9 卷
页码：
收录情况： SCI
摘要： Two new benzoic acids, cladoslide A (1) and cladoslide B (2); one new beta-carboline derivative, cladospomine (3); and one new pyridin-2(1H)-one, cladoslide C (4), were isolated from the fermentation cultures of the mangrove-derived fungus Cladosporium sp. HNWSW-1, along with the previously reported N-acetyl-beta-oxotryptamine (5), (4S,5S,11R)-iso-cladospolide B (6), (4S,5S,11S)-iso-cladospolide B (7), and (4R,5S,11R)-iso-cladospolide B (8). Their structures were elucidated by spectroscopic analysis, Rh-2(OCOCF3)(4)-induced ECD experiments, and Marfey's method. Compound 1 showed cytotoxicity against the K562 cell line with IC50 values of 13.10 +/- 0.08 mu M. Moreover, compounds 1 and 5 exhibited inhibitory activity against alpha-glycosidase with IC50 values of 0.32 +/- 0.01 mM and 0.17 +/- 0.01 mM, respectively.
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