The multiple roles of viral 3Dpol protein in picornavirus infections

文献类型： 外文期刊

第一作者： Nie, Zhenyu

作者： Nie, Zhenyu;Zhai, Fengge;Zhang, Han;Zheng, Haixue;Pei, Jingjing;Nie, Zhenyu;Zhai, Fengge;Zhang, Han;Zheng, Haixue;Pei, Jingjing;Zhai, Fengge;Zheng, Haixue

作者机构：

关键词： Picornaviruses; 3D(pol); RNA-dependent RNA polymerase; virus-host interaction; RdRp inhibitor

期刊名称：VIRULENCE （ 影响因子：5.2； 五年影响因子：5.9 ）

ISSN： 2150-5594

年卷期： 2024 年 15 卷 1 期

页码：

收录情况： SCI

摘要： The Picornaviridae are a large group of positive-sense, single-stranded RNA viruses, and most research has focused on the Enterovirus genus, given they present a severe health risk to humans. Other picornaviruses, such as foot-and-mouth disease virus (FMDV) and senecavirus A (SVA), affect agricultural production with high animal mortality to cause huge economic losses. The 3D(pol )protein of picornaviruses is widely known to be used for genome replication; however, a growing number of studies have demonstrated its non-polymerase roles, including modulation of host cell biological processes, viral replication complex assembly and localization, autophagy, and innate immune responses. Currently, there is no effective vaccine to control picornavirus diseases widely, and clinical therapeutic strategies have limited efficiency in combating infections. Many efforts have been made to develop different types of drugs to prohibit virus survival; the most important target for drug development is the virus polymerase, a necessary element for virus replication. For picornaviruses, there are also active efforts in targeted 3D(pol )drug development. This paper reviews the interaction of 3Dpol proteins with the host and the progress of drug development targeting 3Dpol.

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