Detection and analysis of enzootic nasal tumor virus 2 in China

文献类型： 外文期刊

第一作者： Li, Pengfei

作者： Li, Pengfei;Yuan, Ligang;Li, Pengfei;Cao, Xiaoan;Wu, Jinyan;Liu, Xiaobo;Mao, Shouhui;Shang, Youjun

作者机构：

关键词： enzootic nasal adenocarcinoma; enzootic nasal tumor virus; full-length genome; goats; phylogenetic analysis

期刊名称：JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION （ 影响因子：1.1； 五年影响因子：1.5 ）

ISSN： 1040-6387

年卷期： 2025 年 37 卷 2 期

页码：

收录情况： SCI

摘要： Enzootic nasal tumor virus 2 (ENTV2), the etiologic agent of enzootic nasal adenocarcinoma (ENA) in goats, is highly prevalent in China and causes significant economic losses to the goat industry. Here we describe the occurrence of ENA on a Dazu black goat farm in Chongqing City. At autopsy, nasal cavity masses were observed within the nose of an affected goat; histologically, the tumor was a nasal adenocarcinoma. The qPCR results demonstrated unequivocally that ENTV2 was the primary pathogen responsible for the tumor in this goat. We also collected nasal swab samples from all 180 goats on the farm; 9 goats tested positive for ENTV2. We generated the sequence of the full-length genome of ENTV2 (named ENTV2CQ, GenBank OR024676) with 7,469 nucleotides from nasal tumors from our case. ENTV2CQ shared the highest nucleotide identity with a previously sequenced isolate, ENTV2FJ (GenBank MK559457.1). ENTV2CQ and ENTV2FJ are located in the same major phylogenetic branch, mainly related to isolates from China from 2015 to 2022, and their phylogeny may be clustered geographically.

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