Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway

文献类型： 外文期刊

第一作者： Zhang, Meng-Ling

作者： Zhang, Meng-Ling;Yang, Qian;Zhu, Yan-Di;Zhang, Ya-Di;Zhao, Xiao-Yan;Dang, Qin-Yu;Huang, Dong-Xu;Zhang, Ming-Yuan;Wei, Yu-Chen;Hu, Zhuo;Cai, Xia-Xia;Gao, Li-Fang;Yu, Huan-Ling;Zhang, Meng-Ling;Liu, Jian;Shan, Yang;Zhang, Meng-Ling;Liu, Jian;Shan, Yang;Zhang, Meng-Ling;Liu, Jian;Shan, Yang;Zhang, Meng-Ling;Liu, Jian;Shan, Yang;Zhang, Rui

作者机构：

关键词： Nobiletin; placenta; hypoxia; RUPP; P53 signaling pathway

期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）

ISSN：

年卷期： 2022 年 14 卷 11 期

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收录情况： SCI

摘要： In this study, we aimed to evaluate the effect of Nobiletin (NOB) on the placenta of Sprague-Dawley (SD) rats that had undergone reduced uterine perfusion pressure (RUPP) surgery and to evaluate the safety of NOB intervention during pregnancy. The results showed that NOB alleviated placental hypoxia, attenuated placental cell apoptosis, and inhibited placental damage in RUPP rats. No side effect of NOB intervention during pregnancy was observed. BeWo cell lines with P53 knockdown were then constructed using lentiviral transfection, and the P53 signaling pathway was found to be essential for NOB to reduce hypoxia-induced apoptosis of the BeWo cell lines. In summary, NOB attenuated hypoxia-induced placental damage by regulating the P53 signaling pathway, and those findings may contribute some insights into the role of NOB in placental development and the prevention of placental-related diseases.

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