Epitope molecularly imprinted polymers based on host-guest interaction: specific recognition of CD59
文献类型： 外文期刊
第一作者： Xu, Yitong
作者： Xu, Yitong;Zhang, Ying;Ma, Jiutong;Jia, Qiong;Zhang, Huifeng
作者机构：
关键词： Epitope imprinting; Host-guest interaction; Tannic acid; CD59
期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.0； 五年影响因子：3.6 ）
ISSN： 0021-9673
年卷期： 2025 年 1755 卷
页码：
收录情况： SCI
摘要： The detection of CD59 is of great clinical importance since it is an important glycoprotein that can serve as a biomarker related to kinds of cancers. In this work, we prepared host-guest interaction based oriented epitope molecularly imprinted polymer (hg-EMIP) for the immobilization of CD59 N-terminal epitopes. Cucurbit[7]uril (CB[7]) and l-phenylalanine (L-phe) were employed as the host and guest; and tannic acid (TA) with abundant hydroxyl groups and diethylenetriamine (DETA) were chosen as the functional monomer and crosslinking agent, respectively. The obtained hg-EMIP can specifically recognize CD59 with the adsorption capacity of 88.2 mg/g and imprinting factor of 5.63, and possesses high reusability. The hg-EMIP-based method possesses a wide linear range (1 ng/mL - 1 mu g/mL) and low limit of detection (0.44 ng/mL), and can be successfully used for the detection of CD59 in human serum sample. This study provides a scheme for the preparation of host-guest based epitope molecularly imprinted polymers for helping to identify potential disease biomarkers efficiently.
分类号：
- 相关文献
作者其他论文 更多>>
-
Bioenhanced remediation of dibutyl phthalate contaminated black soil by immobilized biochar microbiota
作者：Tao, Yue;Wang, Yao;Cui, Yunhe;Sun, Rui;Zhang, Bo;Qu, Jianhua;Zhang, Ying;Cai, Hongguang
关键词：Biochar; DBP; Microbial remediation; Black soil; Soil nutrient
-
Simultaneous profiling of chromatin-associated RNA at targeted DNA loci and RNA-RNA Interactions through TaDRIM-seq
作者：Ding, Cheng;Chen, Guoting;Luan, Shiping;Gao, Runxin;Fan, Yudong;Zhang, Ying;Wang, Xiaoting;Li, Guoliang;Foda, Mohamed F.;Yan, Jiapei;Li, Xingwang;Chen, Guoting;Li, Guoliang;Chen, Guoting;Li, Guoliang;Foda, Mohamed F.;Li, Xingwang;Li, Xingwang
关键词：
-
Enhanced removal of tetracycline from water using MgO-modified g-C3N4 composite: Synthesis optimization and mechanism investigation
作者：Yu, Hui;Gao, Longfei;Zhang, Xinyuan;Zhang, Shuang;Chi, Wenshi;Zhang, Long;Li, Jianzhuo;Tian, Yushi;Zhang, Ying;Cai, Hongguang
关键词：Heterojunction; Photocatalysis; Tetracycline degradation; Wastewater treatment
-
Enhanced remediation of cadmium-contaminated farmland by smooth vetch (Vicia villosa var.) coupled with phosphorus/sulfur co-doped biochar: Synergetic performance and mechanism
作者：Bi, Fuxuan;Jiang, Zhao;Wang, Mengning;Lin, Qiutong;Liu, Xiaoyang;Qu, Jianhua;Zhang, Ying;Fu, Libo;Fan, Hongli;Cao, Weidong
关键词：P/S co-doped; Biochar; Smooth vetch; Cadmium; Synergistic remediation
-
Enrichment of carcinoembryonic antigen by epitope molecularly imprinted polymer based on cucurbituril host-guest interaction
作者：Xu, Yitong;Zhang, Ying;He, Yi;Jia, Qiong;Zhang, Huifeng
关键词：Epitope imprinting; Cucurbit[n]uril; Host-guest interaction; Carcinoembryonic antigen
-
Application of Synthetic Microbial Communities of Kalidium schrenkianum in Enhancing Wheat Salt Stress Tolerance
作者：Zhu, Jing;Jia, Qiong;Tang, Qi-Yong;Osman, Ghenijan;Gu, Mei-Ying;Wang, Ning;Zhang, Zhi-Dong
关键词：
Kalidium schrenkianum ; synthetic microbial communities; wheat; salt stress tolerance -
Dissipation, processing factors and risk assessment of chlorothalonil, chlorfenapyr and difenoconazole residues in chilli peppers from field to table
作者：Shi, Guiyuan;Zhang, Ying;Nie, Min;Huang, Wenyuan;Long, Jiahuan;Long, Hui;Duan, Tingting;Shi, Guiyuan;Nie, Min;Cui, Xinyi
关键词：Pesticide residues; Dissipation; Processing factor; Risk assessment; Chilli pepper
