Conversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acids: bioavailability and dietary regulation

文献类型： 外文期刊

第一作者： Wang, Lei

作者： Wang, Lei;Cheng, Chen;Yu, Xiao;Wan, Xia;Xu, Jiqu;Xiang, Xia;Yang, Jing;Deng, Qianchun;Wang, Lei;Cheng, Chen;Yu, Xiao;Wan, Xia;Xu, Jiqu;Xiang, Xia;Yang, Jing;Deng, Qianchun;Yu, Xiao;Guo, Liang;Kang, Jingxuan;Kang, Jingxuan

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关键词： alpha-linolenic acid; n-3 long-chain polyunsaturated fatty acids; bioavailability; metabolic conversion; dietary regulation; precise delivery system

期刊名称：CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION （ 影响因子：8.8； 五年影响因子：12.0 ）

ISSN： 1040-8398

年卷期： 2024 年

页码：

收录情况： SCI

摘要： N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are essential for physiological requirements and disease prevention throughout life but are not adequately consumed worldwide. Dietary supplementation with plant-derived alpha-linolenic acid (ALA) has the potential to rebalance the fatty acid profile and enhance health benefits but faces challenges such as high beta-oxidation consumption, low hepatic conversion efficiency, and high oxidative susceptibility under stress. This review focuses on the metabolic fate and potential regulatory targets of ALA-containing lipids in vivo, specifically the pathway from the gastrointestinal tract to the lymph, blood circulation, and liver. We propose a hypothesis that positively regulates the conversion of ALA into n-3 LCPUFAs based on the model of "fast" or "slow" absorption, transport, and hepatic metabolic fate. Furthermore, the potential effects of dietary nutrients on the metabolic conversion of ALA into n-3 LCPUFAs are discussed. The conversion of ALA is differentially regulated by structured lipids, phospholipids, other lipids, carbohydrates, specific proteins, amino acids, polyphenols, vitamins, and minerals. Future research should focus on designing a steady-state and precise delivery system for ALA, coupled with specific nutrients or phytochemicals, to effectively improve its metabolic conversion and ultimately achieve synergistic regulation of nutrition and health effects.

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