TGF-β1 reduces the differentiation of porcine IgA-producing plasma cells by inducing IgM+ B cells apoptosis via Bax/Bcl2-Caspase3 pathway
文献类型: 外文期刊
第一作者: Wang, Caiying
作者: Wang, Caiying;Yang, Shanshan;Huang, Xin;Lu, Yabin;Zhang, Yue;Li, Maolin;Zhao, Jing;Li, Shuxian;Liu, Guangliang;Wang, Caiying;Yang, Shanshan;Savelkoul, Huub;Jansen, Christine;Lu, Yabin;Li, Shuxian;Liu, Guangliang;Liu, Guangliang
作者机构: Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Lanzhou Univ,Coll Vet Med, Lanzhou, Peoples R China;Wageningen Univ & Res, Cell Biol & Immunol Grp, Wageningen, Netherlands;Xinjiang Agr Univ, Coll Vet Med, Urumqi, Peoples R China;Gansu Prov Res Ctr Basic Disciplines Pathogen Biol, Lanzhou, Peoples R China
关键词: apoptosis; B cell differentiation; IgA; PEDV; TGF-beta 1; Tregs
期刊名称:FASEB JOURNAL ( 2022影响因子:4.8; 五年影响因子:5.2 )
ISSN: 0892-6638
年卷期: 2023 年 37 卷 10 期
收录情况: SCI
摘要: Transforming growth factor beta 1 (TGF-beta 1) performs a critical role in maintaining homeostasis of intestinal mucosa regulation and controls the survival, proliferation, and differentiation of many immune cells. In this study, we discovered that the infection of porcine epidemic diarrhea virus (PEDV), a coronavirus, upregulated TGF-beta 1 expression via activating Tregs. Besides, recombinant porcine TGF-beta 1 decreased the percentage of CD21(+) B cells within the lymphocyte population in vitro. We further found that TGF-beta 1 reduced the IgA-secreting B cell numbers and also inhibited plasma cell differentiation. Additional investigations revealed that TGF-beta 1 induced the apoptosis of IgM(+) B cells in both peyer's patches (PPs) and peripheral blood (PB) through the activation of the Bax/Bcl2-Caspase3 pathway. Conversely, the application of the TGF-beta 1 signaling inhibitor SB431542 significantly antagonized the TGF-beta 1-induced reduction of IgA secretion and B cell apoptosis and restored plasma cell differentiation. Collectively, TGF-beta 1 plays an important role in regulating the survival and differentiation of porcine IgA-secreting B cells through the classical mitochondrial apoptosis pathway. These findings will facilitate future mucosal vaccine designs that target the regulation of TGF-beta 1 for the control of enteric pathogens in the pig industry.
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