Pharmacokinetics of tilmicosin in plasma, urine and feces after a single intragastric administration in donkey (Equus asinus)
文献类型： 外文期刊
第一作者： Yang, Bowen
作者： Yang, Bowen;Liu, Shijie;Guo, Yanxin;Qu, Honglei;Huang, Shimeng;Zhao, Lihong;Zhang, Jianyun;Ji, Cheng;Ma, Qiugang;Qu, Honglei;Feng, Yulong;Wang, Yantao;Dong, Boying;Dong, Yanjie;Zhao, Shancang
作者机构：
关键词： donkey; excretion; intragastric administration; pharmacokinetics; tilmicosin
期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.3； 五年影响因子：1.4 ）
ISSN： 0140-7783
年卷期： 2024 年
页码：
收录情况： SCI
摘要： Tilmicosin, a macrolide antibiotic, has the potential to treat bacterial infections in donkeys. However, the pharmacokinetics of tilmicosin in donkeys have not been reported. The aim of this study was to investigate the pharmacokinetics of tilmicosin in donkey plasma, urine, and feces after a single intragastric administration to determine the suitability of tilmicosin for donkeys. A total of 5 healthy male donkeys with similar body weights were selected. The donkeys were administered a single dose of 10 mg center dot kg(-1) body weight (BW) tilmicosin by gavage. The concentrations of tilmicosin in plasma, urine, and feces were determined. The results showed that after a single intragastric administration of 10 mg center dot kg(-1) body weight, tilmicosin in donkey plasma reached a maximum concentration of 11.23 +/- 5.37 mg center dot L-1 at 0.80 +/- 0.10 h, with a half-life of 14.49 +/- 7.13 h, a mean residence time of 28.05 +/- 3.05 h, a Cl/F of 0.48 +/- 0.18 L center dot kg(-1) center dot h(-1), and a Vd/F of 9.28 +/- 2.63 Lkg(-1). The percentage of tilmicosin excreted through the urine of donkeys is 2.47%, and the percentage excreted through the feces is 66.43%. Our study provides data to inform the use of tilmicosin in donkeys.
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