文献类型： 外文期刊
第一作者： Tan, Luyi
作者： Tan, Luyi;Zhu, Chenyu;Zhang, Xinyu;Fu, Jiaqi;Huang, Tingting;Zhang, Wenjuan;Zhang, Wenji
作者机构：
关键词： Cancer; Mitochondrial RNA methylation; Mitochondrial RNA methyltransferase; Nuclear-mitochondrial crosstalk; Drugs
期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER （ 影响因子：8.3； 五年影响因子：11.6 ）
ISSN： 0304-419X
年卷期： 2024 年 1879 卷 6 期
页码：
收录情况： SCI
摘要： Mitochondria have a complete and independent genetic system with necessary biological energy for cancer occurrence and persistence. Mitochondrial RNA (mt-RNA) methylation, as a frontier in epigenetics, has linked to cancer progression with growing evidences. This review has comprehensively summarized detailed mechanisms of mt-RNA methylation in regulating cancer proliferation, metastasis, and immune infiltration from the mt-RNA methylation sites, biological significance, and its methyltransferases. The mt-RNA methylation also plays a very significant role via epigenetic crosstalk between nucleus and mitochondria. Importantly, the unique structures and functional characteristics of mt-RNA methyltransferases and the potential targeting treatment drugs for cancer are also analyzed. Revealing human mt-RNA methylation regulatory system and the relationship with cancer will contribute to identifying potential biomarkers and therapeutic targets for precise prevention, detection, intervention and treatment in the future.
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