Plant-inspired visible-light-driven bioenergetic hydrogels for chronic wound healing

文献类型： 外文期刊

第一作者： Jiang, Yuping

作者： Jiang, Yuping;Feng, Xiaomin;Qiao, Xin;Li, Yufeng;Li, Xiaozhuang;Han, Lu;Jiang, Yuping;Feng, Xiaomin;Qiao, Xin;Li, Yufeng;Li, Xiaozhuang;Han, Lu;Yang, Jinguang

作者机构：

关键词： Polyphenol nanoparticles; Photosynthetic thylakoid; Inflammation regulation; Diabetic wound repairing; Hydrogel

期刊名称：BIOACTIVE MATERIALS （ 影响因子：18.0； 五年影响因子：18.2 ）

ISSN：

年卷期： 2024 年 41 卷

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收录情况： SCI

摘要： Chronic bioenergetic imbalances and inflammation caused by hyperglycemia are obstacles that delay diabetic wound healing. However, it is difficult to directly deliver energy and metabolites to regulate intracellular energy metabolism using biomaterials. Herein, we propose a light-driven bioenergetic and oxygen-releasing hydrogel (PTKM@HG) that integrates the thylakoid membrane-encapsulated polyphenol nanoparticles (PTKM NPs) to regulate the energy metabolism and inflammatory response in diabetic wounds. Upon red light irradiation, the PTKM NPs exhibited oxygen generation and H2O2 deletion capacity through a photosynthetic effect to restore hypoxia-induced mitochondrial dysfunction. Meanwhile, the PTKM NPs could produce exogenous ATP and NADPH to enhance mitochondrial function and facilitate cellular anabolism by regulating the leucine-activated mTOR signaling pathway. Furthermore, the PTKM NPs inherited antioxidative and anti-inflammatory ability from polyphenol. Finally, the red light irradiated PTKM@HG hydrogel augmented the survival and migration of cells keratinocytes, and then accelerated angiogenesis and re-epithelialization of diabetic wounds. In short, this study provides possibilities for effectively treating diseases by delivering key metabolites and energy based on such a light-driven bioenergetic hydrogel.

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