Protein restriction followed by realimentation influenced immune system and transcriptome of lamb
文献类型： 外文期刊
第一作者： Cui, K.
作者： Cui, K.;Wang, B.;Zhang, N. F.;Tu, Y.;Diao, Q. Y.
作者机构：
关键词： lamb; protein; gene expression; immunocompetence
期刊名称：ENERGY AND PROTEIN METABOLISM AND NUTRITION
ISSN： 0071-2477
年卷期： 2019 年 138 卷
页码：
收录情况： SCI
摘要： The present study aimed to investigate the effect of early (15 to 60 day-old) protein restriction followed by a realimentation on immune system of lamb based on transcriptome sequencing. Thirtytwo lambs with an initial birth weight of 2.3 +/- 0.20 kg that were weaned on day 15 were randomly divided into two groups. The lambs were fed a basal diet with normal protein level (NPL) or low protein level (LPL) from 15 to 60 d, after which all lambs consumed the same diet with a normal protein level from 61 to 90 d. Protein restriction led to a significant decrease in average daily gain (ADG), body weight and liver weight (P<0.05). Transcriptome analysis showed that 302 or 12 differentially expressed genes (DEGs) were identified during the restriction or recovery periods, respectively (P<0.05). The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that DEGs involved in nutrient metabolism and antioxidant capacity were down-regulated, while vessel development and immunity response-related genes up-regulated. The genes involved in metabolism of tyrosine were still down-regulated in the realimentation phase. Studies in this area indicated the accelerated growth effect of early protein restriction followed by a realimentation of lambs and explored the transcriptomics change of liver which can help to develop feeding strategies to optimize the use of feedstuffs.
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