Avian pathogenic Escherichia coli (APEC): current insights and future challenges

文献类型： 外文期刊

第一作者： Nawaz, Saqib

作者： Nawaz, Saqib;Yin, Huifang;Huang, Cuiqin;Han, Xiangan;Nawaz, Saqib;Wang, Zhihao;Zhang, Yan;Jia, Yuanzheng;Jiang, Wei;Chen, Zhaoguo;Han, Xiangan

作者机构：

关键词： avian pathogenic Escherichia coli; foodborne; zoonotic; virulence

期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 12 期

页码：

收录情况： SCI

摘要： Avian pathogenic Escherichia coli (APEC) causes colibacillosis in avian species, and new investigations have implicated APEC as a possible food- borne zoonotic pathogen. This review analyzes APEC's pathogenic and virulence features, assesses the zoonotic potential, provides an update on antibiotic resistance and vaccine research efforts, and outlines alternate management approaches. Aside from established virulence factors, various additional components, including 2-component systems (TCS), adhesins, secretion systems (SS), invasions, iron acquisition systems, quorum sensing systems (QS), transcriptional regulators (TR), toxins, and genes linked with metabolism, contribute to APEC pathogenesis. APEC may spread to diverse species of birds in all business sectors and can infect birds of varying ages. However, younger birds experience more severe sickness than mature ones, probably due to their developing immune systems, and stress factors such as vaccination, Mycoplasma Infections, poor housing circumstances, respiratory viruses, and other risk factors for secondary infections can all make APEC both primary and secondary pathogens. Understanding these factors will help in generating new and effective treatments. Moreover, APEC O145 was the most prevalent serotype recently reported in all of China. Thus, the APEC's zoonotic potential should not be underrated. Furthermore, it has already been noted that APEC is resistant to almost all antibiotic classes, including carbapenems. A robust vaccine capable of protecting against multiple APEC serotypes is urgently needed. Alternative medications, particularly virulence inhibitors, can provide a special method with a decreased likelihood of acquiring resistance.

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