Effects of Vitamin A on Growth Performance, Antioxidants, Gut Inflammation, and Microbes in Weaned Piglets

文献类型： 外文期刊

第一作者： Wu, Shengnan

作者： Wu, Shengnan;Wang, Li;Cui, Bailei;Wen, Xiaolu;Jiang, Zongyong;Hu, Shenglan;Wu, Shengnan;Wang, Li;Cui, Bailei;Wen, Xiaolu;Jiang, Zongyong;Hu, Shenglan;Wu, Shengnan;Wang, Li;Cui, Bailei;Wen, Xiaolu;Jiang, Zongyong;Hu, Shenglan;Wu, Shengnan;Wang, Li;Cui, Bailei;Wen, Xiaolu;Jiang, Zongyong;Hu, Shenglan;Wu, Shengnan;Wang, Li;Cui, Bailei;Wen, Xiaolu;Jiang, Zongyong;Hu, Shenglan

作者机构：

关键词： vitamin A; antioxidant; weaned piglets; growth performance; gut microbiota; inflammation

期刊名称：ANTIOXIDANTS （ 影响因子：7.0； 五年影响因子：7.3 ）

ISSN：

年卷期： 2023 年 12 卷 12 期

页码：

收录情况： SCI

摘要： Piglet weaning is an important stage in production where changes in the environment and diet can cause problems such as intestinal inflammation and diarrhea. Vitamin A is an essential nutrient for human and animal growth and has immunomodulatory and inflammatory effects. A large body of literature has previously reported on the use of vitamin A in piglet production, so our experiment added different concentrations of vitamin A (0, 1100, 2200, 4400, 8800, and 17,600 IU/kg) to weaned piglet diets to study the effects of different doses on growth performance, intestinal barrier, inflammation, and flora in weaned piglets. We selected 4400 IU/kg as the optimum concentration of vitamin A in relation to average daily weight gain, feed intake, feed-to-weight ratio, and diarrhea rate, and subsequently tested the inflammatory factors, immunoglobulin content, antioxidant levels, and intestinal flora of weaned piglets. Results: We observed that the diarrhea rate of weaned piglets was significantly lower after the addition of 4400 IU/kg of vitamin A to the diet (p < 0.05). A control group and a 4400 IU/kg VA group were selected for subsequent experiments. We found that after the addition of vitamin A, the serum CAT level of weaned piglets increased significantly, the expression of Claudin-1 in the jejunum and ileum increased significantly, the expression of Occludin gene in the jejunum increased significantly, the expression of IL-5 and IL-10 in the ileum increased significantly (p < 0.05), and the expression of IL-4, IL-5, and IL-10 in the ileum increased significantly (p < 0.05). Meanwhile, in the colonic flora of vitamin A-added weaned piglets, the relative abundance of Actinobacteria and Erysipelotrichales decreased significantly, while the relative abundance of Bacteroidales increased significantly (p < 0.05). The results of this study indicated that vitamin A at 4400 IU/kg reduces diarrhea in weaned piglets by increasing antioxidant levels, increasing intestinal tight junction protein gene expression, and regulating colonic gut microbiota.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序