The Immune Efficacy of Inactivated Pseudorabies Vaccine Prepared from FJ-2012 Delta gE/gI Strain

文献类型： 外文期刊

第一作者： Chen, Qiu-Yong

作者： Chen, Qiu-Yong;Wu, Xue-Min;Che, Yong-Liang;Chen, Ru-Jing;Hou, Bo;Wang, Chen-Yan;Wang, Long-Bai;Zhou, Lun-Jiang;Chen, Qiu-Yong;Wu, Xue-Min;Che, Yong-Liang;Chen, Ru-Jing;Hou, Bo;Wang, Chen-Yan;Wang, Long-Bai;Zhou, Lun-Jiang

作者机构：

关键词： pseudorabies virus; inactivated vaccine; vaccine efficacy; control

期刊名称：MICROORGANISMS （ 影响因子：4.926； 五年影响因子：5.143 ）

ISSN：

年卷期： 2022 年 10 卷 10 期

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收录情况： SCI

摘要： An emerging pseudorabies virus (PRV) variant has been reported on Bartha-K61-vaccinated farms since 2011, causing great economic losses to China's swine-feeding industry. In this study, two vaccines, FJ-2012 Delta gE/gI-GEL02 and FJ-2012 Delta gE/gI-206VG, were administered to piglets for immune efficacy investigation. Humoral immunity response, clinical signs, survival rate, tissue viral load, and pathology were assessed in piglets. The results showed that both vaccines were effective against the PRV FJ-2012 challenge, the piglets all survived while developing a high level of gB-specific antibody and neutralizing antibody, the virus load in tissue was alleviated, and no clinical PR signs or pathological lesions were displayed. In the unimmunized challenged group, typical clinical signs of pseudorabies were observed, and the piglets all died at 7 days post-challenge. Compared with commercial vaccines, the Bartha-K61 vaccine group could not provide full protection, which might be due to a lower vaccine dose; the inactivated vaccine vPRV* group piglets survived, displaying mild clinical signs. The asterisk denotes inactivation. These results indicate that FJ-2012 Delta gE/gI-GEL02 and FJ-2012 Delta gE/gI-206VG were effective and could be promising vaccines to control or eradicate the new PRV epidemic in China.

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