Barley Grass Juice Attenuates Hydrodynamic Transfection-Induced HCC Initiation in Mice

文献类型： 外文期刊

第一作者： Li, Jing

作者： Li, Jing;Xu, Hongwei;Zhou, Longhua;Guo, Huimin;Zhang, Shuwei;Lu, Ruiju;Chang, Mengling;Liu, Chenghong;Li, Jing;Li, Jing;Zhang, Wen;Liang, Xiao;Chang, Mengling

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期刊名称：NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL （ 影响因子：2.816； 五年影响因子：3.095 ）

ISSN： 0163-5581

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收录情况： SCI

摘要： Barley (Hordeum vulgare L.) grass has been recognized as a functional food with a wide spectrum of health-promoting properties. Supplementation with barley grass has the potential to prevent chronic diseases, such as cancer. Here, we investigated whether barley grass could protect against hepatocellular carcinoma (HCC). Our data showed that administration of barley grass juice attenuates tumor development in a hydrodynamic gene delivery-induced model of HCC. The expression levels of the immune cell markers Ptprc and Adgre1 were upregulated in the barley grass juice-treated and normal groups, compared to those in the vehicle group in the HCC model. Immune cells (CD45+, F4/80+, and CLEC4F + iNOS + cells) infiltration in the liver increased following barley grass juice administration. Our results indicate that barley grass could be beneficial for HCC alleviation, partly by regulating immune cell infiltration. The ingredients of barley grass affect immune cell infiltration in HCC, and the detailed mechanism requires further study.

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