Antioxidant effects of Bifidobacterium longum T37a in mice weight loss and aging model induced by D-galactose

文献类型： 外文期刊

第一作者： Wang, Ya

作者： Wang, Ya;Wang, Jiahui;Li, Hehai;Lao, Jianlong;Jia, Dan;Li, Youquan;Wang, Ya;Wang, Jiahui;Wang, Jiahui;Jia, Dan;Liu, Junlong;Wang, Jinming;Luo, Jianxun;Guan, Guiquan;Yin, Hong;Li, Youquan

作者机构：

关键词： Bifidobacterium longum; Antioxidant; Anti-aging

期刊名称：BMC MICROBIOLOGY （ 影响因子：4.2； 五年影响因子：4.7 ）

ISSN： 1471-2180

年卷期： 2023 年 23 卷 1 期

页码：

收录情况： SCI

摘要： BackgroundProbiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp. from faeces of babies, and investigate the antioxidant effects of the Bif. longum T37a in mice weight loss and aging model induced by D-galactose.ResultsT37a have good antioxidant properties in the DPPH assay and anti-lipid peroxidation test. Compared with the model group, T37a low group significantly increased the thymus index and the levels of T-AOC and GSH-Px of mice. T37a high group significantly decreased the spleen and liver index of mice and the levels of MDA in liver, significantly increased in liver HDL-C levels, and decreased LDL-C in liver.ConclusionsT37a may be an anti-aging and weight-loss probiotics for its antioxidant capacity, and it is necessary to study further the molecular mechanism of T37a as antioxidant.

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