Antioxidant Activity of Tartary Buckwheat Bran Extract and Its Effect on the Lipid Profile of Hyperlipidemic Rats

文献类型： 外文期刊

第一作者： Wei, Yi-Min

作者： Wei, Yi-Min;Wang, Min;Liu, Jia-Ren;Gao, Jin-Ming;Parry, John W.

作者机构：

关键词： Tartary buckwheat bran extract;serum lipids;ORAC;hepatic lipids;antioxidant enzyme;malondialdehyde;hyperlipidemic rats

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

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收录情况： SCI

摘要： The effects of Tartary buckwheat bran extract (TBBE) on antioxidation status and on lipid profile were determined in hyperlipemic rats. Seven-week-old male Wistar rats were fed a high-fat diet to induce hyperlipemia with doses of TBBE at 0.2 (low), 0.5 (medium), and 1.0 (high) g/kg of body weight. The positive control group was fed the high-fat diet or supplemented with Gynostemma pantaphyllum total glucoside tablet at 0.032 g/kg of body weight. The negative control group was fed the basal diet. The blood lipids, liver lipids, and antioxidant-related parameters of the rats were measured. The rats fed TBBE indicated that TBBE could effectively reduce serum total triglycerides (TG) and total cholesterol (TC) when compared to the control groups (P < 0.05). TBBE also reduced liver TC and TG by 36.4 and 73.9% in the low-dose group when compared to the high-fat group (P < 0.05), respectively, presenting remarkable effects in serum triglyceride reduction, antiathero-sclerosis, and serum-lipid oxidation resistance. TBBE also raised serum glutathione peroxidase (GSH-Px) activity and antiatheromatous plaque formation index (AAI) and lowered the atherogenic index of plasma (AIP), the artherogenic index (Al), and serum malondialdehyde (MDA) in comparison with the control groups (P < 0.05 or P < 0.01). In this study, TBBE was shown to significantly reduce the TG and TC in the serum and liver of rats, raise serum antioxidant activity, and inhibit serum lipid peroxide formation.

分类号： TQ

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