Antibiotic exposure alters the honeybee gut microbiota and may interfere with the honeybee behavioral caste transition

文献类型： 外文期刊

第一作者： Zhang, Zijing

作者： Zhang, Zijing;Mu, Xiaohuan;Cao, Qina;Zheng, Hao;Zhai, Yifan;Zheng, Li;Liu, Yan;Zhai, Yifan;Zheng, Li;Liu, Yan;Zhang, Xue

作者机构：

关键词： antibiotic resistance; Apis mellifera; behavioral development; immune genes

期刊名称：INSECT SCIENCE （ 影响因子：4.0； 五年影响因子：3.6 ）

ISSN： 1672-9609

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Behavioral division is essential for the sustainability and reproduction of honeybee populations. While accumulating evidence has documented that antibiotic exposure interferes with bee behavioral divisions, how the gut microbiome, host physiology, and genetic regulation are implicated in this process remains understudied. Here, by constructing single-cohort colonies, we validated that the gut microbiota varied in composition between age-matched nurse and forager bees. Perturbing the gut microbiota with a low dose of antibiotic retained the gut bacterial size, but the structure of the microbial community continuously diverged from the control group after antibiotic treatment. Fewer foragers were observed in the antibiotic groups in the field experiment. A combinatorial effect of decreased gut metabolic gene repertoires, reduced brain neurotransmitter titers, and downregulated brain immune genes could potentially be related to behavioral tasks transition delay. This work indicates that the disturbance to both the gut microbiome and host physiologies after antibiotic exposure may have implications on social behavior development, highlighting the need for further research focusing on antibiotic pollution threatening the honeybee population's health.

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