Molecular farming expression of recombinant fusion proteins applied to skincare strategies

文献类型： 外文期刊

第一作者： Yu, Guangdong

作者： Yu, Guangdong;Zhao, Wengang;Xu, Nuo;Wang, Yunpeng

作者机构：

关键词： Molecular farming; Skincare; Arabidopsis; Transdermal peptide; Epidermal growth factor

期刊名称：PEERJ （ 影响因子：2.4； 五年影响因子：2.7 ）

ISSN： 2167-8359

年卷期： 2024 年 12 卷

页码：

收录情况： SCI

摘要： This review discusses the current research progress in molecular farming technology in the fi eld of skincare, with an emphasis on molecular farming expression strategies. The strategies of transdermal drug delivery and their advantages are also highlighted. The expression of cosmetically relevant fused proteins has become an important way to enhance the efficacy fi cacy of the proteins. Therefore, we also discuss the feasibility and strategies for expressing fusion proteins in A. thaliana, , specifically fi cally the fusion of Epidermal growth factor (EGF) to a cell-penetrating peptide (CPP), in which the production can be greatly enhanced via plant expression systems since these systems offer higher biosecurity, fl exibility, and expansibility than prokaryotic, animal and mammalian expression systems. While the fusion of EGF to CCP can enhance its transdermal ability, the effects of the fusion protein on skin repair, melasma, whitening, and anti-aging are poorly explored. Beyond this, fusing proteins with transdermal peptides presents multiple possibilities for the development of tissue repair and regeneration therapeutics, as well as cosmetics and beauty products. As certain plant extracts are known to contain proteins beneficial fi cial for skin health, the expression of these proteins in plant systems will better maintain their integrity and biological activities, thereby facilitating the development of more effective skincare products.

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