FucP promotes the pathogenicity of Edwardsiella piscicida to infect zebrafish

文献类型： 外文期刊

第一作者： Zhang, Xinya

作者： Zhang, Xinya;Mu, Cuimin;Chen, Jiakang;Pan, Guangchen;Wang, Xuepeng;Zhang, Xinya;Wang, Xuepeng;Yan, Maocang;Wu, Jiayan

作者机构：

关键词： Edwardsiella piscicida; FucP; T3SS; Fucose; Pathogenicity

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.216； 五年影响因子：3.812 ）

ISSN： 2352-5134

年卷期： 2021 年 20 卷

页码：

收录情况： SCI

摘要： Edwardsiella piscicida (E. piscicida) is an important zoonotic pathogen that mostly infects fish by colonizing the intestine. Fucose within the intestine could regulate the pathogenicity of some intestinal pathogens. Here we identified the function of fucose permease in E. piscicida and its physiological influence. The results showed that E. piscicida grew faster in the presence of L-fucose. The fucose permease gene fucP mutant strain Delta fucP significantly decreased penetration and motility in mucin compared with the wild-type strain. The gene expression levels of esaB, esaD, esaL and esaK in Delta fucP had significantly downregulated when compared with the wild-type strain. Most importantly, the survival rate of zebrafish after being infected with Delta fucP was significantly higher than those of the wild type. In a word, fucose promoted the growth and motility of E. piscicida and the fucP gene mutant decreased the pathogenicity of E. piscicida in zebrafish.

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