In vivo antioxidant activity of rabbiteye blueberry (Vaccinium ashei cv. 'Brightwell') anthocyanin extracts

文献类型： 外文期刊

第一作者： Wang, Jing

作者： Wang, Jing;Huang, Wuyang;Zhao, Xingyu;Zheng, Jiawei;Zhang, Xiaoxiao;Huang, Wuyang;Zhao, Xingyu;Zheng, Jiawei;Zhang, Xiaoxiao;Huang, Wuyang;Herrera-Balandrano, Daniela D.;Sui, Zhongquan

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关键词： Blueberry anthocyanin; In vivo antioxidant activity; Superoxide dismutase (SOD); Glutathione-peroxidase (GSH-PX; GPX); Malondialdehyde (MDA)

期刊名称：JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B （ 影响因子：5.1； 五年影响因子：4.1 ）

ISSN： 1673-1581

年卷期： 2023 年 24 卷 7 期

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收录情况： SCI

摘要： Blueberries are rich in phenolic compounds including anthocyanins which are closely related to biological health functions. The purpose of this study was to investigate the antioxidant activity of blueberry anthocyanins extracted from 'Brightwell' rabbiteye blueberries in mice. After one week of adaptation, C57BL/6J healthy male mice were divided into different groups that were administered with 100, 400, or 800 mg/kg blueberry anthocyanin extract (BAE), and sacrificed at different time points (0.1, 0.5, 1, 2, 4, 8, or 12 h). The plasma, eyeball, intestine, liver, and adipose tissues were collected to compare their antioxidant activity, including total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity and glutathione-peroxidase (GSH-PX/GPX) content, and the oxidative stress marker malondialdehyde (MDA) level. The results showed that blueberry anthocyanins had positive concentration-dependent antioxidant activity in vivo. The greater the concentration of BAE, the higher the T-AOC value, but the lower the MDA level. The enzyme activity of SOD, the content of GSH-PX, and messenger RNA (mRNA) levels of Cu, Zn-SOD, Mn-SOD, and GPX all confirmed that BAE played an antioxidant role after digestion in mice by improving their antioxidant defense. The in vivo antioxidant activity of BAE indicated that blueberry anthocyanins could be developed into functional foods or nutraceuticals with the aim of preventing or treating oxidative stress-related diseases.

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