Preclinical Safety Assessment of Deferoxamine-preconditioned Canine Adipose Tissue-derived Mesenchymal Stem Cells

文献类型： 外文期刊

第一作者： Ji, Xinpeng

作者： Ji, Xinpeng;Jin, Shiyu;Teng, Hailong;Zhou, Yuze;Li, Qiang;Ji, Xinpeng;Li, Xiangzi;Li, Qiang;Zhang, Junfang;Choi, Seong-ho

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关键词： Deferoxamine; preconditioning; canine; mesenchymal stem cells; safety

期刊名称：IN VIVO （ 影响因子：1.8； 五年影响因子：1.8 ）

ISSN： 0258-851X

年卷期： 2024 年 38 卷 6 期

页码：

收录情况： SCI

摘要： Background/Aim: In the pursuit of translating stem cell therapy technology into clinical practice, ensuring the safety and efficacy of treatments is paramount. Despite advancements, the effectiveness of stem cell applications often falls short of clinical requirements. This study aimed to address the challenge of limited efficacy by investigating the safety and effectiveness of canine adipose tissue-derived mesenchymal stem cells (cATMSCs) preconditioned with deferoxamine (DFO). Materials and Methods: Different concentrations of DFO were used to evaluate its impact on cATMSC activity. The therapeutic potential of these preconditioned cells was validated using a mouse model of systemic inflammation. Comprehensive evaluations, including clinical hematological and radiological assessments before and after intravenous injection of preconditioned cells were conducted. Results: The study showed a notable reduction in inflammatory markers and an overall decrease in the inflammatory response in the mouse model. The

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