A geniposide-phospholipid complex ameliorates posthyperuricemia chronic kidney disease induced by inflammatory reactions and oxidative stress

文献类型： 外文期刊

第一作者： Wang, Mu-xuan

作者： Wang, Mu-xuan;Liao, Zhi-xin;Wang, Mu-xuan;Liao, Zhi-xin;Liu, Chao;Chen, Jia-shu;Guo, Xu;Zhang, Meng-qi;Zhang, Jing;Sun, Jin-yue;Wang, Min-min;Chen, Jia-shu

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关键词： Hyperuricemia; Chronic kidney disease; Geniposide-phospholipid complex; Inflammatory reaction; Oxidative stress

期刊名称：EUROPEAN JOURNAL OF PHARMACOLOGY （ 影响因子：5.195； 五年影响因子：4.721 ）

ISSN： 0014-2999

年卷期： 2022 年 930 卷

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收录情况： SCI

摘要： Hyperuricemia is a common metabolic disease and is one of the factors that could induce chronic kidney disease (CKD). Geniposide (GEN) is a typical natural iridoid glucoside compound with a series of biological activities, but the poor bioavailability of GEN limits its clinical application. In this context, the pharmacological activity of the geniposide-phospholipid complex (GEN-PLC) in ameliorating posthyperuricemia CKD was evaluated by in vitro and in vivo experiments in this study. In vitro cell experiments showed that GEN-PLC treatment markedly decreased inflammatory cytokine levels and reactive oxygen species levels compared with those of GEN in uric acid-treated HKC cells. In vivo research results confirmed that a high concentration of uric acid could cause CKD by increasing inflammatory cytokines and reactive oxygen species in hyperuricemic mice. At the same time, GEN-PLC could regulate the PI3K/AKT/NF-kappa B and Keap1/Nrf2/HO-1 signaling pathways to effectively inhibit the inflammatory response and oxidative stress, thereby ameliorating posthyperuricemia CKD, and the thera-peutic effect was better than that of GEN. In addition, the preparation technology of GEN-PLC was optimized, and the physiochemical analysis explained the intermolecular interactions of the two components. Based on the research results, GEN-PLC could enhance the bioavailability of GEN and become a promising candidate for clinical drug development.

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