Integrated Metabolomics and Metagenomics Unveiled Biomarkers of Antioxidant Potential in Fermented Brewer's Grains

文献类型： 外文期刊

第一作者： Qamar, Hammad

作者： Qamar, Hammad;He, Rong;Song, Min;Deng, Dun;Cui, Yiyan;Yang, Pan;Liu, Zhichang;Yu, Miao;Ma, Xianyong;Li, Yuanfei;Waqas, Muhammad;Qammar, Bilal;Asnan, Muhammad;Xie, Xiangxue;Yu, Miao;Ma, Xianyong

作者机构：

关键词： antioxidants; fermentation; Lactobacillus; enzymes; metagenomics; metabolomics; isoflavonoids; flavonoids; phenylpropanoids; brewer's spent grain

期刊名称：ANTIOXIDANTS （ 影响因子：6.0； 五年影响因子：6.7 ）

ISSN：

年卷期： 2024 年 13 卷 7 期

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收录情况： SCI

摘要： About one-third of the global food supply is wasted. Brewers' spent grain (BSG), being produced in enormous amounts by the brewery industry, possesses an eminence nutritional profile, yet its recycling is often neglected for multiple reasons. We employed integrated metagenomics and metabolomics techniques to assess the effects of enzyme treatments and Lactobacillus fermentation on the antioxidant capacity of BSG. The biotreated BSG revealed improved antioxidant capability, as evidenced by significantly increased (p < 0.05) radical scavenging activity and flavonoid and polyphenol content. Untargeted metabolomics revealed that Lactobacillus fermentation led to the prominent synthesis (p < 0.05) of 15 novel antioxidant peptides, as well as significantly higher (p < 0.05) enrichment of isoflavonoid and phenylpropanoid biosynthesis pathways. The correlation analysis demonstrated that Lactiplantibacillus plantarum exhibited strong correlation (p < 0.05) with aucubin and carbohydrate-active enzymes, namely, glycoside hydrolases 25, glycosyl transferases 5, and carbohydrate esterases 9. The fermented BSG has potential applications in the food industry as a culture medium, a functional food component for human consumption, and a bioactive feed ingredient for animals.

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