Phytoalexin sakuranetin attenuates endocytosis and enhances resistance to rice blast

文献类型： 外文期刊

第一作者： Jiang, Lihui

作者： Jiang, Lihui;Zhang, Xiaoyan;Zhao, Yiting;Zhu, Haiyan;Fu, Qijing;Lu, Xinqi;Huang, Wuying;Yang, Xinyue;Zhou, Xuan;Wu, Lixia;Yang, Ao;He, Xie;Dong, Man;Peng, Ziai;Yang, Jing;Guo, Liwei;Huang, Huichuan;Xie, Yong;Zhu, Shusheng;Li, Chengyun;Zhu, Youyong;Du, Yunlong;Zhao, Yiting;Yang, Jing;Guo, Liwei;Huang, Huichuan;Xie, Yong;Zhu, Shusheng;Li, Chengyun;Zhu, Youyong;Du, Yunlong;Yang, Jing;Guo, Liwei;Huang, Huichuan;Xie, Yong;Zhu, Shusheng;Li, Chengyun;Zhu, Youyong;Du, Yunlong;Wen, Jiancheng;He, Xiahong;Friml, Jiri

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）

ISSN：

年卷期： 2024 年 15 卷 1 期

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收录情况： SCI

摘要： Phytoalexin sakuranetin functions in resistance against rice blast. However, the mechanisms underlying the effects of sakuranetin remains elusive. Here, we report that rice lines expressing resistance (R) genes were found to contain high levels of sakuranetin, which correlates with attenuated endocytic trafficking of plasma membrane (PM) proteins. Exogenous and endogenous sakuranetin attenuates the endocytosis of various PM proteins and the fungal effector PWL2. Moreover, accumulation of the avirulence protein AvrCO39, resulting from uptake into rice cells by Magnaporthe oryzae, was reduced following treatment with sakuranetin. Pharmacological manipulation of clathrin-mediated endocytic (CME) suggests that this pathway is targeted by sakuranetin. Indeed, attenuation of CME by sakuranetin is sufficient to convey resistance against rice blast. Our data reveals a mechanism of rice against M. oryzae by increasing sakuranetin levels and repressing the CME of pathogen effectors, which is distinct from the action of many R genes that mainly function by modulating transcription. Sakuranetin is an important phytoalexin. The authors find that sakuranetin in rice attenuates endocytosis of effectors from the fungus Magnaporthe oryzae and enhances resistance against rice blast.

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